The analysis was controlled for several factors that could influence participants’ mental health independently of whether they received hormone treatment: age at the time of the survey; gender identity; sex assigned at birth; sexual orientation; race or ethnicity; level of family support for gender identity; relationship status; level of education; employment status; household income; use of pubertal suppression treatment; any attempts to force them to be cisgender; and experience of any verbal, physical or sexual harassment based on their gender identity in grades K-12.
Compared with members of the control group, participants who underwent hormone treatment had lower odds of experiencing severe psychological distress during the previous month and lower odds of suicidal ideation in the previous year. Odds of severe psychological distress were reduced by 222%, 153% and 81% for those who began hormones in early adolescence, late adolescence and adulthood, respectively. Odds of previous-year suicidal ideation were 135% lower in people who began hormones in early adolescence, 62% lower in those who began in late adolescence and 21% lower in those who began as adults, compared with the control group.
In addition, participants who began hormones in early or late adolescence had lower odds of past-month binge drinking and lifetime illicit drug use than those who began hormones in adulthood.
But the researchers found that those who started hormone treatment in adulthood were more likely to engage in binge drinking and use of illicit substances than those who never accessed the treatment. “Some individuals may become more confident and socially engaged when they begin taking hormones,” Turban said, adding that, in some cases, this increased confidence and social engagement may be linked to substance use. “This finding speaks to the importance of creating culturally tailored substance-use counseling programs for transgender individuals.”
To get a sense of whether participants’ mental health before treatment influenced their ability to gain access to treatment, the researchers also assessed whether participants in each group had ever been suicidal but had not had suicidal feelings in the previous year.
“This was a measure of mental health improving over time,” Turban said. “People were more likely to meet those criteria if they accessed and took hormones than if they hadn’t.” The finding implies that access to hormones improved mental health rather than the other way around, he said.
Building evidence for gender-affirming medical care
Turban and his colleagues hope legislators across the country will use the new findings to inform their policy decisions. Although several bills to ban gender-affirming medical care for transgender youth have been introduced in state legislatures in recent years, nearly all have failed to become law, he said, adding that all major medical organizations support provision of gender-affirming medical care, including hormone therapy for patients who desire it and who meet criteria set out by the Endocrine Society and the World Professional Association for Transgender Health.
“There’s no one correct way to be transgender,” Turban said. Some transgender people do not want to take hormones and feel comfortable with their bodies the way they are. Young people seeking care at gender clinics are routinely offered counseling as part of their treatment to help them figure out what types of care best fit their circumstances.
For those who desire gender-affirming hormones, being denied access to the treatment can cause significant distress, Turban said.
“For some transgender youth, their negative reactions to living in bodies that develop during puberty in ways that don’t match who they know themselves to be can be very damaging,” he said. For instance, individuals who feel uncomfortable developing breasts may react by binding their chests so tightly they develop skin infections or rib fractures.
“These results won’t be surprising to providers, but unfortunately a lot of legislators have never met any transgender youth,” Turban said. “It’s important for legislators to see the numbers that back up the experiences of transgender youth, their families and the people who work in this field.”
Researchers from The Fenway Institute, Brigham and Women’s Hospital, Harvard Medical School, and the Harvard T.H. Chan School of Public Health contributed to the study.
The research was funded by the American Academy of Child & Adolescent Psychiatry (supported by industry sponsors Arbor and Pfizer), the Harvey L. and Maud C. Sorensen Foundation, the National Institute of Mental Health (grant MH094612), and the Health Resources and Services Administration (grant U30CS22742).